Persons at High Risk of Influenza Complications
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| Children <5 years and especially those <2 years,a regardless of the presence of underlying medical conditions |
| Adults ≥50 years and especially those ≥65 years |
| Children and adults with chronic pulmonary (including asthma and cystic fibrosis), hemodynamically significant cardiovascular disease (except hypertension alone), or renal, hepatic, hematologic (including sickle cell disease and other hemoglobinopathies), or metabolic disorders (including diabetes mellitus) |
| Children and adults with immunosuppression attributable to any cause, including that caused by medications or by HIV infection |
| Children and adults with neurologic and neurodevelopment conditions (including disorders of the brain, spinal cord, peripheral nerve, and muscle such as cerebral palsy, epilepsy, stroke, intellectual disability, moderate-to-severe developmental delay, muscular dystrophy, or spinal cord injury) |
| Children and adults with conditions that compromise respiratory function or handling of secretions (including tracheostomy and mechanical ventilation)12 |
| Women who are pregnant or postpartum during the influenza season |
| Children and adolescents <19 years who are receiving long-term aspirin therapy or salicylate-containing medications (including those with Kawasaki disease and rheumatologic conditions) because of increased risk of Reye syndrome |
| American Indian and Alaskan native people |
| Children and adults with extreme obesity (ie, BMI ≥40 for adults and based on age for children) |
| Residents of chronic care facilities and nursing homes |
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| Children <5 years and especially those <2 years,a regardless of the presence of underlying medical conditions |
| Adults ≥50 years and especially those ≥65 years |
| Children and adults with chronic pulmonary (including asthma and cystic fibrosis), hemodynamically significant cardiovascular disease (except hypertension alone), or renal, hepatic, hematologic (including sickle cell disease and other hemoglobinopathies), or metabolic disorders (including diabetes mellitus) |
| Children and adults with immunosuppression attributable to any cause, including that caused by medications or by HIV infection |
| Children and adults with neurologic and neurodevelopment conditions (including disorders of the brain, spinal cord, peripheral nerve, and muscle such as cerebral palsy, epilepsy, stroke, intellectual disability, moderate-to-severe developmental delay, muscular dystrophy, or spinal cord injury) |
| Children and adults with conditions that compromise respiratory function or handling of secretions (including tracheostomy and mechanical ventilation)12 |
| Women who are pregnant or postpartum during the influenza season |
| Children and adolescents <19 years who are receiving long-term aspirin therapy or salicylate-containing medications (including those with Kawasaki disease and rheumatologic conditions) because of increased risk of Reye syndrome |
| American Indian and Alaskan native people |
| Children and adults with extreme obesity (ie, BMI ≥40 for adults and based on age for children) |
| Residents of chronic care facilities and nursing homes |
The 2019–2020 CDC recommendations state that “Although all children younger than 5 years old are considered at higher risk for complications from influenza, the highest risk is for those younger than 2 years old, with the highest hospitalization and death rates among infants younger than 6 months old.”