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TABLE 3

ADI Level

SweetenerJECFA ADI, mg/kgEFSA ADI, mg/kgDVFA ADI, mg/kgFDA ADI, mg/kgNumber of Packets Equivalent to ADI (Based on a 68-kg Person)
Saccharin (Sweet’N Low) 15 250 
Aspartame (NutraSweet and Equal) 40 40 15 50 165 
Acesulfame potassium (Sweet One) 15 40 15 165 
Sucralose (Splenda) 15 15 15 165 
Neotame 0–2 Unknown 0.3 200 
Stevia Unknown 12 30 
Advantame 0–5 4000 33 4000 
SweetenerJECFA ADI, mg/kgEFSA ADI, mg/kgDVFA ADI, mg/kgFDA ADI, mg/kgNumber of Packets Equivalent to ADI (Based on a 68-kg Person)
Saccharin (Sweet’N Low) 15 250 
Aspartame (NutraSweet and Equal) 40 40 15 50 165 
Acesulfame potassium (Sweet One) 15 40 15 165 
Sucralose (Splenda) 15 15 15 165 
Neotame 0–2 Unknown 0.3 200 
Stevia Unknown 12 30 
Advantame 0–5 4000 33 4000 

Adapted from US Food and Drug Administration. Food additives and ingredients. Available at: www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients. Accessed March 26, 2019; Gardner C, Wylie-Rosett J, Gidding SS, et al; American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity and Metabolism, Council on Arteriosclerosis, Thrombosis and Vascular Biology, Council on Cardiovascular Disease in the Young, and the American Diabetes Association. Nonnutritive sweeteners: current use and health perspectives: a scientific statement from the American Heart Association and the American Diabetes Association. Circulation. 2012;126(4):509–519; and Mattes RD, Popkin BM. Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr. 2009;89(1):1–14. DVFA, Danish Veterinary and Food Administration; EFSA, European Food and Safety Agency; JECFA, Joint Food and Agriculture Organization of the United Nations–World Health Organization Expert Committee on Food Additives.

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