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TABLE 2

Association of Perioperative RBC Transfusion and Development of Postoperative VTE Within 30 d in All Children Aged 0 to 18 y

Exposure VariableNo. Patients30-d Postoperative VTE
No. (%)OR (95% CI)aOR (95% CI)a
Neonates     
 Perioperative RBC transfusion     
  No 17 313 43 (0.2) Ref. Ref. 
  Yes 3179 56 (1.8) 7.2 (4.8–10.7) 4.1 (2.5–6.7) 
 Time of perioperative RBC transfusion     
  None 17 313 43 (0.2) Ref. Ref. 
  Preoperative only 466 7 (1.5) 6.1 (2.7–13.7) 3.7 (1.5–8.7) 
  Intraoperative or postoperative only 1925 29 (1.5) 6.1 (3.8–9.9) 3.7 (2.2–6.4) 
  Preoperative and intraoperative 788 20 (2.5) 10.5 (6.1–17.9) 6.4 (3.2–12.7) 
Infants     
 Perioperative RBC transfusion     
  No 72 721 78 (0.1) Ref. Ref. 
  Yes 7023 69 (1.0) 9.2 (6.7–12.8) 2.4 (1.7–3.6) 
 Time of perioperative RBC transfusion     
  None 72 721 78 (0.1) Ref. Ref. 
  Preoperative only 1066 8 (0.8) 7.0 (3.4–14.6) 1.5 (0.7–3.2) 
  Intraoperative or postoperative only 5321 47 (0.9) 8.3 (5.8–11.9) 2.7 (1.8–4.1) 
  Preoperative and intraoperative 636 14 (2.2) 21.0 (11.8–37.2) 2.3 (1.2–4.6) 
Children     
 Perioperative RBC transfusion     
  No 362 152 252 (0.1) Ref. Ref. 
  Yes 20 710 122 (0.6) 8.5 (6.9–10.6) 2.2 (1.7–2.9) 
 Time of perioperative RBC transfusion     
  None 362 152 252 (0.1) Ref. Ref. 
  Preoperative only 1594 12 (0.8) 10.9 (6.1–19.5) 1.8 (1.0–3.3) 
  Intraoperative or postoperative only 18 682 93 (0.5) 7.2 (5.7–9.1) 2.2 (1.6–2.8) 
  Preoperative and intraoperative 434 17 (3.9) 58.5 (35.5–96.6) 3.7 (2.1–6.5) 
Exposure VariableNo. Patients30-d Postoperative VTE
No. (%)OR (95% CI)aOR (95% CI)a
Neonates     
 Perioperative RBC transfusion     
  No 17 313 43 (0.2) Ref. Ref. 
  Yes 3179 56 (1.8) 7.2 (4.8–10.7) 4.1 (2.5–6.7) 
 Time of perioperative RBC transfusion     
  None 17 313 43 (0.2) Ref. Ref. 
  Preoperative only 466 7 (1.5) 6.1 (2.7–13.7) 3.7 (1.5–8.7) 
  Intraoperative or postoperative only 1925 29 (1.5) 6.1 (3.8–9.9) 3.7 (2.2–6.4) 
  Preoperative and intraoperative 788 20 (2.5) 10.5 (6.1–17.9) 6.4 (3.2–12.7) 
Infants     
 Perioperative RBC transfusion     
  No 72 721 78 (0.1) Ref. Ref. 
  Yes 7023 69 (1.0) 9.2 (6.7–12.8) 2.4 (1.7–3.6) 
 Time of perioperative RBC transfusion     
  None 72 721 78 (0.1) Ref. Ref. 
  Preoperative only 1066 8 (0.8) 7.0 (3.4–14.6) 1.5 (0.7–3.2) 
  Intraoperative or postoperative only 5321 47 (0.9) 8.3 (5.8–11.9) 2.7 (1.8–4.1) 
  Preoperative and intraoperative 636 14 (2.2) 21.0 (11.8–37.2) 2.3 (1.2–4.6) 
Children     
 Perioperative RBC transfusion     
  No 362 152 252 (0.1) Ref. Ref. 
  Yes 20 710 122 (0.6) 8.5 (6.9–10.6) 2.2 (1.7–2.9) 
 Time of perioperative RBC transfusion     
  None 362 152 252 (0.1) Ref. Ref. 
  Preoperative only 1594 12 (0.8) 10.9 (6.1–19.5) 1.8 (1.0–3.3) 
  Intraoperative or postoperative only 18 682 93 (0.5) 7.2 (5.7–9.1) 2.2 (1.6–2.8) 
  Preoperative and intraoperative 434 17 (3.9) 58.5 (35.5–96.6) 3.7 (2.1–6.5) 
a

The multivariable models included adjustment for sex, race, age, ASA class, central line, preoperative sepsis status, preoperative ventilation status, disseminated cancer status, and the work-related RVU, hospital length of stay. Model for neonates also was adjusted for preterm birth status. RVUs were modeled continuously using a square root transformation.

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