Skip to Main Content
TABLE 1

List of Commonly Used Drugs Metabolized by CYP2D6 (List Is Nonexhaustive)

Drug CategoriesDrugs
Antineoplastic agent Tamoxifen 
Antipsychotics Clozapine, haloperidol, risperidone, zuclopenthixol, flupenthixol, aripiprazole, and fluvoxamine 
Antiarrhythmics Propafenone, flecainide, and lidocaine 
β-blockers Carvedilol, metoprolol, and propranolol 
Opioids Codeine, oxycodone, and tramadol 
SSRIs and SNRIs Fluoxetine, paroxetine, venlafaxine, duloxetine, and sertraline 
Tricyclic antidepressants Amitriptyline, nortriptyline, clomipramine, doxepin, imipramine, and atomoxetine 
Prokinetic agent Metoclopramide 
Adrenergic agonist Clonidine 
5-HT3 receptor antagonist Ondansetron 
Antihistamines Chlorpheniramine and diphenhydramine 
Calcium channel blocker Diltiazem 
Drug CategoriesDrugs
Antineoplastic agent Tamoxifen 
Antipsychotics Clozapine, haloperidol, risperidone, zuclopenthixol, flupenthixol, aripiprazole, and fluvoxamine 
Antiarrhythmics Propafenone, flecainide, and lidocaine 
β-blockers Carvedilol, metoprolol, and propranolol 
Opioids Codeine, oxycodone, and tramadol 
SSRIs and SNRIs Fluoxetine, paroxetine, venlafaxine, duloxetine, and sertraline 
Tricyclic antidepressants Amitriptyline, nortriptyline, clomipramine, doxepin, imipramine, and atomoxetine 
Prokinetic agent Metoclopramide 
Adrenergic agonist Clonidine 
5-HT3 receptor antagonist Ondansetron 
Antihistamines Chlorpheniramine and diphenhydramine 
Calcium channel blocker Diltiazem 

Adapted from O’Hara K, Wright IMR, Schneider JJ, Jones AL, Martin JH. Pharmacokinetics in neonatal prescribing: evidence base, paradigms and the future. Br J Clin Pharmacol. 2015;80(6):1283. Adapted from Gopisankar MG. CYP2D6 pharmacogenomics. Egyptian Journal of Medical Human Genetics. 2017;18(4):312. Adapted from Indiana University. Drug interactions: cytochrome P450 drug interaction table. 2007. Available at: https://drug-interactions.medicine.iu.edu/. Accessed September 23, 2019. Adapted from Samer CF, Lorenzini KI, Rollason V, Daali Y, Desmeules JA. Applications of CYP450 testing in the clinical setting. Mol Diagn Ther. 2013;17(3):167. SNRI, serotonin and norepinephrine reuptake inhibitor; SSRI, selective serotonin reuptake inhibitor; 5-HT3, serotonin type 3.

Close Modal

or Create an Account

Close Modal
Close Modal