TABLE 1

Prevalence and Classification of DDIs Across US Children’s Hospitals

No. Encounters With DDIPercentage of Hospitalizations With DDI ExposureTotal Patient-Days With DDI ExposureDDI Exposure Rate per 1000 d (All Hospitalized Patients)DDI Exposure Rate per 1000 d (DDI Patients Only)
Any DDI 47 414 2.03 328 585 34.91 370.72 
Risk grade      
 X: avoid combination 11 734 0.50 28 644 3.04 221.27 
 D: consider treatment modification 12 841 0.55 103 820 11.03 117.13 
 C: monitor therapy 26 651 1.14 196 121 20.84 32.32 
No. Encounters With DDIPercentage of Hospitalizations With DDI ExposureTotal Patient-Days With DDI ExposureDDI Exposure Rate per 1000 d (All Hospitalized Patients)DDI Exposure Rate per 1000 d (DDI Patients Only)
Any DDI 47 414 2.03 328 585 34.91 370.72 
Risk grade      
 X: avoid combination 11 734 0.50 28 644 3.04 221.27 
 D: consider treatment modification 12 841 0.55 103 820 11.03 117.13 
 C: monitor therapy 26 651 1.14 196 121 20.84 32.32 

Number of encounters = 2 331 305; number of hospital days = 9 412 578; number of hospital days for DDI exposed cases = 886 354.

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