American Academy of Pediatrics

TABLE 2

Associations Between LV Diastolic Function (E/é Ratio) and Childhood Risk Factors

	Childhood Model			Combined Model
	Estimate	SE	P	Estimate	SE	P
Female sex	0.084	0.066	.202	−0.217	0.072	.003
Age, y	0.093	0.022	<.001	0.084	0.023	<.001
Height in adulthood, cm	−0.140	0.031	<.001	−0.137	0.032	<.001
Cumulative systolic blood pressure in childhood	0.100	0.022	<.001	0.015	0.025	.557
Cumulative physical activity in childhood	−0.061	0.023	.007	−0.053	0.024	.029
Cumulative adiposity in childhood	0.091	0.025	<.001	0.075	0.028	.007
Systolic blood pressure in adulthood, mm Hg	—	—	—	0.180	0.025	<.001
Physical activity in adulthood (index score 5–15)	—	—	—	0.018	0.022	.410
Adiposity in adulthood, cm	—	—	—	0.039	0.028	.166

	Childhood Model			Combined Model
	Estimate	SE	P	Estimate	SE	P
Female sex	0.084	0.066	.202	−0.217	0.072	.003
Age, y	0.093	0.022	<.001	0.084	0.023	<.001
Height in adulthood, cm	−0.140	0.031	<.001	−0.137	0.032	<.001
Cumulative systolic blood pressure in childhood	0.100	0.022	<.001	0.015	0.025	.557
Cumulative physical activity in childhood	−0.061	0.023	.007	−0.053	0.024	.029
Cumulative adiposity in childhood	0.091	0.025	<.001	0.075	0.028	.007
Systolic blood pressure in adulthood, mm Hg	—	—	—	0.180	0.025	<.001
Physical activity in adulthood (index score 5–15)	—	—	—	0.018	0.022	.410
Adiposity in adulthood, cm	—	—	—	0.039	0.028	.166

Both models were additionally adjusted for study center. Childhood cumulative parameters were calculated as AUC variables from estimated participant-specific curves (age window 6–18 y). Explanatory variables were standardized (mean 0 and SD 1). —, not applicable.

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