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TABLE 2

Associations Between LV Diastolic Function (E/é Ratio) and Childhood Risk Factors

Childhood ModelCombined Model
EstimateSEPEstimateSEP
Female sex 0.084 0.066 .202 −0.217 0.072 .003 
Age, y 0.093 0.022 <.001 0.084 0.023 <.001 
Height in adulthood, cm −0.140 0.031 <.001 −0.137 0.032 <.001 
Cumulative systolic blood pressure in childhood 0.100 0.022 <.001 0.015 0.025 .557 
Cumulative physical activity in childhood −0.061 0.023 .007 −0.053 0.024 .029 
Cumulative adiposity in childhood 0.091 0.025 <.001 0.075 0.028 .007 
Systolic blood pressure in adulthood, mm Hg — — — 0.180 0.025 <.001 
Physical activity in adulthood (index score 5–15) — — — 0.018 0.022 .410 
Adiposity in adulthood, cm — — — 0.039 0.028 .166 
Childhood ModelCombined Model
EstimateSEPEstimateSEP
Female sex 0.084 0.066 .202 −0.217 0.072 .003 
Age, y 0.093 0.022 <.001 0.084 0.023 <.001 
Height in adulthood, cm −0.140 0.031 <.001 −0.137 0.032 <.001 
Cumulative systolic blood pressure in childhood 0.100 0.022 <.001 0.015 0.025 .557 
Cumulative physical activity in childhood −0.061 0.023 .007 −0.053 0.024 .029 
Cumulative adiposity in childhood 0.091 0.025 <.001 0.075 0.028 .007 
Systolic blood pressure in adulthood, mm Hg — — — 0.180 0.025 <.001 
Physical activity in adulthood (index score 5–15) — — — 0.018 0.022 .410 
Adiposity in adulthood, cm — — — 0.039 0.028 .166 

Both models were additionally adjusted for study center. Childhood cumulative parameters were calculated as AUC variables from estimated participant-specific curves (age window 6–18 y). Explanatory variables were standardized (mean 0 and SD 1). —, not applicable.

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