Effect of Vitamin D Supplementation on RSS at 18 Months in Intention-To-Treat Analysis
| . | Placebo (n = 310) . | Vitamin D (n = 321) . | P . |
|---|---|---|---|
| Range | 0–10 | 0–3 | — |
| Median (IQR) | 0 (0–1) | 0 (0–0.5) | — |
| Mean (95% CI) | 0.46 (0.36 to 0.56) | 0.35 (0.28 to 0.42) | .086 |
| Rickets, n (%) | |||
| RSS ≤ 1.5 | 293 (94.5) | 304 (94.7) | — |
| RSS >1.5 | 17 (5.5) | 17 (5.3) | — |
| Risk of rickets, OR (95% CI) | 1.0 (reference) | 0.96 (0.48 to 1.92) | .917 |
| RSS, mean (95% CI) | |||
| Calcium <300 mg/day (n = 265) | 0.57 (0.37 to 0.77) | 0.39 (0.28 to 0.50) | .106 |
| Calcium ≥ 300 mg/day (n = 270) | 0.44 (0.31 to 0.57) | 0.29 (0.20 to 0.39) | .081 |
| . | Placebo (n = 310) . | Vitamin D (n = 321) . | P . |
|---|---|---|---|
| Range | 0–10 | 0–3 | — |
| Median (IQR) | 0 (0–1) | 0 (0–0.5) | — |
| Mean (95% CI) | 0.46 (0.36 to 0.56) | 0.35 (0.28 to 0.42) | .086 |
| Rickets, n (%) | |||
| RSS ≤ 1.5 | 293 (94.5) | 304 (94.7) | — |
| RSS >1.5 | 17 (5.5) | 17 (5.3) | — |
| Risk of rickets, OR (95% CI) | 1.0 (reference) | 0.96 (0.48 to 1.92) | .917 |
| RSS, mean (95% CI) | |||
| Calcium <300 mg/day (n = 265) | 0.57 (0.37 to 0.77) | 0.39 (0.28 to 0.50) | .106 |
| Calcium ≥ 300 mg/day (n = 270) | 0.44 (0.31 to 0.57) | 0.29 (0.20 to 0.39) | .081 |
Dietary calcium was available for 268 children in the placebo (n = 126 with calcium <300 mg/day and n = 142 with calcium ≥ 300 mg/day) and 267 children in the vitamin D group (n = 139 with calcium <300 mg/day and n = 128 with calcium ≥ 300 mg/day). OR, odds ratio; —, not applicable.