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TABLE 1

Definitions of Terms Used in the CHA IPSO QI Learning Collaborative

TermDefinition
IPSO suspected infection Hospitalized patients or ED patients designated for admission who had a blood culture collected and an antibiotic administered within 24 h of each other 
IPSO sepsis Hospitalized patients or ED patients who met ≥1 of the following 8 criteria29 : a bedside screen positive for sepsisa and treatment of sepsis,b a positive huddle for sepsis,c use of an electronic medical record order set for severe sepsis or use of an electronic medical record order set for sepsis that included treatment of sepsis,b ICU admission and treatment of sepsis,b collection of a venous or arterial lactate level and treatment of sepsis,b administration of a vasopressor and treatment of sepsis,b use of ICD-10 billing codes R65.20 or R65.21, or use of other specified sepsis ICD-10 billing codes and treatment of sepsisb 
IPSO critical sepsis Hospitalized patients or ED patients who met the IPSO sepsis definition and met ≥1 of the following criteria: administration of a first antibiotic plus 2 IV fluid boluses (all within 6 h of each other) plus administration of a third IV fluid bolus, administration of a first antibiotic plus 2 IV fluid boluses (all within 6 h of each other) plus administration of a vasopressor, or administration of a first antibiotic plus an IV fluid bolus plus administration of a vasopressor (all within 6 h of each other) 
Sepsis-attributable mortality Patients who met the IPSO sepsis definition and who died were reviewed to determine if the patient had IPSO sepsis and no comorbid conditions or had a comorbid condition but had not fully recovered from all sepsis-related organ dysfunction before death 
TermDefinition
IPSO suspected infection Hospitalized patients or ED patients designated for admission who had a blood culture collected and an antibiotic administered within 24 h of each other 
IPSO sepsis Hospitalized patients or ED patients who met ≥1 of the following 8 criteria29 : a bedside screen positive for sepsisa and treatment of sepsis,b a positive huddle for sepsis,c use of an electronic medical record order set for severe sepsis or use of an electronic medical record order set for sepsis that included treatment of sepsis,b ICU admission and treatment of sepsis,b collection of a venous or arterial lactate level and treatment of sepsis,b administration of a vasopressor and treatment of sepsis,b use of ICD-10 billing codes R65.20 or R65.21, or use of other specified sepsis ICD-10 billing codes and treatment of sepsisb 
IPSO critical sepsis Hospitalized patients or ED patients who met the IPSO sepsis definition and met ≥1 of the following criteria: administration of a first antibiotic plus 2 IV fluid boluses (all within 6 h of each other) plus administration of a third IV fluid bolus, administration of a first antibiotic plus 2 IV fluid boluses (all within 6 h of each other) plus administration of a vasopressor, or administration of a first antibiotic plus an IV fluid bolus plus administration of a vasopressor (all within 6 h of each other) 
Sepsis-attributable mortality Patients who met the IPSO sepsis definition and who died were reviewed to determine if the patient had IPSO sepsis and no comorbid conditions or had a comorbid condition but had not fully recovered from all sepsis-related organ dysfunction before death 

ICD-10, International Classification of Diseases, 10th Revision; IV, intravenous.

a

Determined at individual sites but generally consistent with the Pediatric Sepsis and Septic Shock Collaborative definition, which includes assessment of underlying risk and abnormal vital signs, perfusion, and mental status.16 

b

Administration of an antibiotic and an IV fluid bolus plus either a second IV fluid bolus or administration of a vasopressor (all within 6 h of each other) plus a blood culture collected within 72 h of the episode.

c

A brief, focused discussion that includes a nurse, a provider (physician, physician assistant, or nurse practitioner), and additional staff as needed (eg, rapid response team, code sepsis team, or care team) during which a determination is made that the patient will be treated for sepsis.

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