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Key Action Statement Profile: KAS 4A

Aggregate evidence quality Grade B 
Benefits Effective antibiotic for most children with AOM. Inexpensive, safe, acceptable taste, narrow antimicrobial spectrum. 
Risks, harms, cost Ineffective against β-lactamase–producing organisms. Adverse effects of amoxicillin. 
Benefits-harms assessment Preponderance of benefit. 
Value judgments Better to use a drug that has reasonable cost, has an acceptable taste, and has a narrow antibacterial spectrum. 
Intentional vagueness The clinician must determine whether the patient is truly penicillin allergic. 
Role of patient preferences Should be considered if previous bad experience with amoxicillin. 
Exclusions Patients with known penicillin allergy. 
Strength Recommendation. 
Aggregate evidence quality Grade B 
Benefits Effective antibiotic for most children with AOM. Inexpensive, safe, acceptable taste, narrow antimicrobial spectrum. 
Risks, harms, cost Ineffective against β-lactamase–producing organisms. Adverse effects of amoxicillin. 
Benefits-harms assessment Preponderance of benefit. 
Value judgments Better to use a drug that has reasonable cost, has an acceptable taste, and has a narrow antibacterial spectrum. 
Intentional vagueness The clinician must determine whether the patient is truly penicillin allergic. 
Role of patient preferences Should be considered if previous bad experience with amoxicillin. 
Exclusions Patients with known penicillin allergy. 
Strength Recommendation. 
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