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TABLE 2

Association Between Tdap Vaccination During Pregnancy and Pediatric Health Outcomes, Ontario, Canada

Tdap Vaccination During PregnancyNo Tdap Vaccination During PregnancyCrude Estimate (95% CI)Adjusted Estimate From Matched Sample (95% CI)
No. EventsIncidence Rate (95% CI) per 1000 Person-YearsNo. EventsIncidence Rate (95% CI) per 1000 Person-Years
Atopic disease       
 Asthmaa,b 461 28.2 (25.7–30.9) 43 757 28.4 (28.1–28.7) 0.95 (0.87–1.04) 0.93 (0.82–1.04) 
Infectious disease       
 Upper respiratory infectionsc 4303 135.3 (129.7–141.1) 311 405 144.8 (144.0–145.6) 0.93 (0.90–0.97) 0.94 (0.90–0.99) 
 Lower respiratory infectionsc 1787 56.2 (53.0–59.6) 129 960 60.4 (60.0–60.9) 0.93 (0.88–0.99) 0.94 (0.88–1.00) 
 Gastrointestinal infectionsc 1077 33.9 (31.7–36.2) 77 783 36.2 (35.9–36.5) 0.94 (0.88–1.00) 0.85 (0.79–0.91) 
 Otitis mediac 1851 58.2 (54.8–61.8) 137 293 63.9 (63.4–64.4) 0.91 (0.86–0.97) 0.97 (0.91–1.04) 
Non-immune-related morbidity outcomes       
 Neoplasmb 14 0.44 (0.26–0.74) 658 0.31 (0.28–0.33) 1.51 (1.07–2.13) 1.36 (0.76–2.44) 
 Sensory disordersb 0.25 (0.13–0.50) 764 0.36 (0.33–0.38) 0.70 (0.35–1.41) 0.72 (0.34–1.52) 
Nonspecific morbidity outcome       
 Rates of urgent and inpatient health service utilizationc 22 965 722.1 (703.6–741.5) 1 615 068 751.1 (748.3–753.9) 0.96 (0.94–0.99) 0.93 (0.91–0.96) 
Negative-control outcome       
 All-cause injuriesb 2527 90.6 (87.2–94.1) 172 244 95.9 (95.4–96.3) 1.32 (1.27–1.38) 0.99 (0.95–1.03) 
Tdap Vaccination During PregnancyNo Tdap Vaccination During PregnancyCrude Estimate (95% CI)Adjusted Estimate From Matched Sample (95% CI)
No. EventsIncidence Rate (95% CI) per 1000 Person-YearsNo. EventsIncidence Rate (95% CI) per 1000 Person-Years
Atopic disease       
 Asthmaa,b 461 28.2 (25.7–30.9) 43 757 28.4 (28.1–28.7) 0.95 (0.87–1.04) 0.93 (0.82–1.04) 
Infectious disease       
 Upper respiratory infectionsc 4303 135.3 (129.7–141.1) 311 405 144.8 (144.0–145.6) 0.93 (0.90–0.97) 0.94 (0.90–0.99) 
 Lower respiratory infectionsc 1787 56.2 (53.0–59.6) 129 960 60.4 (60.0–60.9) 0.93 (0.88–0.99) 0.94 (0.88–1.00) 
 Gastrointestinal infectionsc 1077 33.9 (31.7–36.2) 77 783 36.2 (35.9–36.5) 0.94 (0.88–1.00) 0.85 (0.79–0.91) 
 Otitis mediac 1851 58.2 (54.8–61.8) 137 293 63.9 (63.4–64.4) 0.91 (0.86–0.97) 0.97 (0.91–1.04) 
Non-immune-related morbidity outcomes       
 Neoplasmb 14 0.44 (0.26–0.74) 658 0.31 (0.28–0.33) 1.51 (1.07–2.13) 1.36 (0.76–2.44) 
 Sensory disordersb 0.25 (0.13–0.50) 764 0.36 (0.33–0.38) 0.70 (0.35–1.41) 0.72 (0.34–1.52) 
Nonspecific morbidity outcome       
 Rates of urgent and inpatient health service utilizationc 22 965 722.1 (703.6–741.5) 1 615 068 751.1 (748.3–753.9) 0.96 (0.94–0.99) 0.93 (0.91–0.96) 
Negative-control outcome       
 All-cause injuriesb 2527 90.6 (87.2–94.1) 172 244 95.9 (95.4–96.3) 1.32 (1.27–1.38) 0.99 (0.95–1.03) 
a

Cohort for asthma is restricted to children with a minimum of 3 y of follow-up.

b

Number of events represents the total number of children diagnosed with the outcome. Incidence rates are based on the full study population. Point estimates are hazard ratios generated from a Cox proportional hazards model.

c

Number of events represents the total number of occurrences for each outcome. Incidence rates are based on the full study population. Point estimates are incidence rate ratios generated from a Poisson regression model.

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