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TABLE 1

Abridged Data Dictionary With Variables, Definitions, and Percentages Reported in the IPSO Sepsis Cohort

Variable (Ordered by Reporting Frequency)Data Dictionary Variable DefinitionIPSO Sepsis Cohort (Reported in Descending Order), %
Arrival time Time patient arrived at the ED or was admitted to the hospital directly 100.0 
Functional T0 See T0 diagram, Fig 1  99.3 
Bolus 1 time Time that first fluid bolus began; vol <5 mL/kg should not be counted as a bolus 98.4 
First antibiotic time Time that first IV antibiotic (antibacterial) was started, whether the antibiotic was effective or not; intramuscular or intraosseous used for sepsis also acceptable 97.5 
IV antibiotic days The No. days the patient is on IV antibiotics within the 30 d after T0; use whole numbers only; if the patient is on IV antibiotics for one-half a day, count as 1 d; if the patient is on multiple antibiotics, each antibiotic counts as a day (for example, 3 d of 2 antibiotics = 6 d) 97.1 
Bolus 3 volume Volume of the third bolus in milliliters; vol <5 mL/kg should not be counted as a bolus 97.1 
Bolus 2 time Time that second fluid bolus began; vol <5 mL/kg should not be counted as a bolus 95.8 
Vasoactive agent type Indicates what kind of vasoactive agent was first used; the target time is within 24 h after T0 95.8 
Birthdate Patient’s date of birth 95.5 
First vasoactive time Time the first vasoactive agent was used 95.5 
ICU d No. days the patient was in the ICU for any part of the day beginning at T0 until discharge, death, or 30 d, whichever comes first; do not include ICU days before T0; if the patient was not in the ICU, report 0 d 95.3 
Bolus 3 time Time that third fluid bolus began; vol <5 mL/kg should not be counted as a bolus 95.3 
Bolus 2 volume Volume of the second bolus in milliliters; vol <5 mL/kg should not be counted as a bolus 94.4 
Time hematology or oncology from ED Time of patient transfer between hematology and oncology service and the ED 93.9 
Wt Patient’s wt in kilograms 93.5 
Time ICU from hematology or oncology Time of patient transfer between the ICU and hematology or oncology service 93.2 
Positive pressure ventilation d The No. days the patient was on ventilation for any part of the day beginning at T0 until discharge, death, or 30 d, whichever comes first; include days in which the patient had noninvasive ventilation, such as BIPAP or CPAP; do include ventilator days before T0 93.1 
Time ICU from general care Time of patient transfer between the ICU and acute care or general care service 93.1 
Vasoactive d No. days the patient was on pressors for any part of the day beginning at T0 until discharge, death, or 30 d, whichever comes first; do not include vasoactive days before T0 93.0 
Lactic acid time Time first lactic acid was obtained; do not capture lactic acid from an outside hospital, only the first one at your institution 93.0 
Time general care from ED Time of patient transfer between the ED and the acute care or general care service 93.0 
Time ICU from ED Time of patient transfer between the ICU and the ED 92.9 
T0 location The location of the patient at the time of functional T0 92.8 
Order set Time of first use of either (1) any component of a severe sepsis order set or (2) a related infection‐specific order set that includes core severe sepsis components; for example, a pneumonia order set 92.4 
Bolus 1 volume Volume of the first bolus in milliliters; vol <5 mL/kg should not be counted as a bolus 92.1 
Lactic acid value Initial lactic acid value 91.5 
Sepsis screen Time of initial screening process to identify possible severe sepsis in patient when screen result was positive; the initial screening process may consist of an electronic alert, a checklist, Pediatric Early Warning Scores (absolute value and/or change), bedside nursing screens, or other identification tools; the initial screening process may use paper‐based tools or electronic tools 91.3 
Extracorporeal membrane oxygenation Indicates if patient was placed on extracorporeal membrane oxygenation within 30 d of T0 88.9 
First hypotension time If the patient was hypotensive, this is the time of the first documented hypotension. Use what your institution classifies as hypotensive. 87.7 
Central venous line time Time of placement of central venous line in patient, if within time frame of 72 h before T0 to 72 h after T0 87.0 
Outside hospital specified Indicates if a patient arrived at your hospital from another hospital or facility in the 24 h before T0 86.7 
Blood culture result positive Indicates whether there was a positive blood culture result for the patient; blood culture results from an outside hospital or primary care provider can be used 85.7 
Chronically ventilated Indicates whether the patient was chronically ventilated or used BIPAP or CPAP as baseline for any portion of the day 84.5 
Time surgical source control Time of surgical procedure to control the source of the patient’s infection (including definitive management of abscess, peritonitis, line infection, bone or joint infection, empyema, or infected hardware); if the procedure was within 48 h before T0 to 48 h after T0 75.2 
Huddle time Time of sepsis team huddle to review clinical findings and determine if that patient is on a severe sepsis pathway in cases in which the huddle result was positive 74.2 
Mixed venous oxygen saturation time Time of obtaining mixed venous saturation for patient, if within time frame of 72 h (72 h before T0 to 72 h after T0) 69.2 
Organ dysfunction Indicate if and when organ dysfunction occurred after. Organ dysfunction would include ≥1 of the following: cardiovascular, respiratory, renal, hepatic, hematologic, or neurologic per Goldstein et al26  definitions. These data may require clinician review of the patient’s chart. 53.0 
High-risk condition other than not applicable The patient’s underlying high-risk conditions documented in ED or on admission; may require manual chart review to determine malignancy, asplenia (including sickle cell), bone marrow transplant, indwelling line or catheter, solid organ transplant, global developmental delay or cerebral palsy, immunocompromise or suppression, technology dependence (gastrostomy tube, tracheostomy tube, or ventriculoperitoneal shunt) 41.3 
Clinically derived T0 The date and time of the patient’s onset of physiologic sepsis, as determined by manual chart review; we recommend using the Goldstein et al26  definitions; this definition is different from functional T0 32.2 
Risk score Using your hospital’s standard risk-scoring tool, report the risk score for the patient. You may use the Pediatric Index of Mortality, PRISM, or another risk-scoring tool. 11.4 
Risk score method Name of the tool or scoring method used to assess a risk of mortality score 10.8 
Other International Classification of Diseases, 10th Revision sepsis codes A02.1, A20.7, A21.7, A22.7, A24.1, A26.7, A32.7, A39.2, A39.3, A39.4, A40.0, A40.1, A40.3, A40.8, A40.9, A41.01, A41.02, A41.1, A41.2, A41.3, A41.4, A41.50, A41.51, A41.52, A41.53, A41.59, A41.81, A41.89, A41.9, A42.7, A54.86, B00.7, B37.7 N/A 
International Classification of Diseases, 10th Revision severe sepsis, septic shock R65.20, R65.21 N/A 
Variable (Ordered by Reporting Frequency)Data Dictionary Variable DefinitionIPSO Sepsis Cohort (Reported in Descending Order), %
Arrival time Time patient arrived at the ED or was admitted to the hospital directly 100.0 
Functional T0 See T0 diagram, Fig 1  99.3 
Bolus 1 time Time that first fluid bolus began; vol <5 mL/kg should not be counted as a bolus 98.4 
First antibiotic time Time that first IV antibiotic (antibacterial) was started, whether the antibiotic was effective or not; intramuscular or intraosseous used for sepsis also acceptable 97.5 
IV antibiotic days The No. days the patient is on IV antibiotics within the 30 d after T0; use whole numbers only; if the patient is on IV antibiotics for one-half a day, count as 1 d; if the patient is on multiple antibiotics, each antibiotic counts as a day (for example, 3 d of 2 antibiotics = 6 d) 97.1 
Bolus 3 volume Volume of the third bolus in milliliters; vol <5 mL/kg should not be counted as a bolus 97.1 
Bolus 2 time Time that second fluid bolus began; vol <5 mL/kg should not be counted as a bolus 95.8 
Vasoactive agent type Indicates what kind of vasoactive agent was first used; the target time is within 24 h after T0 95.8 
Birthdate Patient’s date of birth 95.5 
First vasoactive time Time the first vasoactive agent was used 95.5 
ICU d No. days the patient was in the ICU for any part of the day beginning at T0 until discharge, death, or 30 d, whichever comes first; do not include ICU days before T0; if the patient was not in the ICU, report 0 d 95.3 
Bolus 3 time Time that third fluid bolus began; vol <5 mL/kg should not be counted as a bolus 95.3 
Bolus 2 volume Volume of the second bolus in milliliters; vol <5 mL/kg should not be counted as a bolus 94.4 
Time hematology or oncology from ED Time of patient transfer between hematology and oncology service and the ED 93.9 
Wt Patient’s wt in kilograms 93.5 
Time ICU from hematology or oncology Time of patient transfer between the ICU and hematology or oncology service 93.2 
Positive pressure ventilation d The No. days the patient was on ventilation for any part of the day beginning at T0 until discharge, death, or 30 d, whichever comes first; include days in which the patient had noninvasive ventilation, such as BIPAP or CPAP; do include ventilator days before T0 93.1 
Time ICU from general care Time of patient transfer between the ICU and acute care or general care service 93.1 
Vasoactive d No. days the patient was on pressors for any part of the day beginning at T0 until discharge, death, or 30 d, whichever comes first; do not include vasoactive days before T0 93.0 
Lactic acid time Time first lactic acid was obtained; do not capture lactic acid from an outside hospital, only the first one at your institution 93.0 
Time general care from ED Time of patient transfer between the ED and the acute care or general care service 93.0 
Time ICU from ED Time of patient transfer between the ICU and the ED 92.9 
T0 location The location of the patient at the time of functional T0 92.8 
Order set Time of first use of either (1) any component of a severe sepsis order set or (2) a related infection‐specific order set that includes core severe sepsis components; for example, a pneumonia order set 92.4 
Bolus 1 volume Volume of the first bolus in milliliters; vol <5 mL/kg should not be counted as a bolus 92.1 
Lactic acid value Initial lactic acid value 91.5 
Sepsis screen Time of initial screening process to identify possible severe sepsis in patient when screen result was positive; the initial screening process may consist of an electronic alert, a checklist, Pediatric Early Warning Scores (absolute value and/or change), bedside nursing screens, or other identification tools; the initial screening process may use paper‐based tools or electronic tools 91.3 
Extracorporeal membrane oxygenation Indicates if patient was placed on extracorporeal membrane oxygenation within 30 d of T0 88.9 
First hypotension time If the patient was hypotensive, this is the time of the first documented hypotension. Use what your institution classifies as hypotensive. 87.7 
Central venous line time Time of placement of central venous line in patient, if within time frame of 72 h before T0 to 72 h after T0 87.0 
Outside hospital specified Indicates if a patient arrived at your hospital from another hospital or facility in the 24 h before T0 86.7 
Blood culture result positive Indicates whether there was a positive blood culture result for the patient; blood culture results from an outside hospital or primary care provider can be used 85.7 
Chronically ventilated Indicates whether the patient was chronically ventilated or used BIPAP or CPAP as baseline for any portion of the day 84.5 
Time surgical source control Time of surgical procedure to control the source of the patient’s infection (including definitive management of abscess, peritonitis, line infection, bone or joint infection, empyema, or infected hardware); if the procedure was within 48 h before T0 to 48 h after T0 75.2 
Huddle time Time of sepsis team huddle to review clinical findings and determine if that patient is on a severe sepsis pathway in cases in which the huddle result was positive 74.2 
Mixed venous oxygen saturation time Time of obtaining mixed venous saturation for patient, if within time frame of 72 h (72 h before T0 to 72 h after T0) 69.2 
Organ dysfunction Indicate if and when organ dysfunction occurred after. Organ dysfunction would include ≥1 of the following: cardiovascular, respiratory, renal, hepatic, hematologic, or neurologic per Goldstein et al26  definitions. These data may require clinician review of the patient’s chart. 53.0 
High-risk condition other than not applicable The patient’s underlying high-risk conditions documented in ED or on admission; may require manual chart review to determine malignancy, asplenia (including sickle cell), bone marrow transplant, indwelling line or catheter, solid organ transplant, global developmental delay or cerebral palsy, immunocompromise or suppression, technology dependence (gastrostomy tube, tracheostomy tube, or ventriculoperitoneal shunt) 41.3 
Clinically derived T0 The date and time of the patient’s onset of physiologic sepsis, as determined by manual chart review; we recommend using the Goldstein et al26  definitions; this definition is different from functional T0 32.2 
Risk score Using your hospital’s standard risk-scoring tool, report the risk score for the patient. You may use the Pediatric Index of Mortality, PRISM, or another risk-scoring tool. 11.4 
Risk score method Name of the tool or scoring method used to assess a risk of mortality score 10.8 
Other International Classification of Diseases, 10th Revision sepsis codes A02.1, A20.7, A21.7, A22.7, A24.1, A26.7, A32.7, A39.2, A39.3, A39.4, A40.0, A40.1, A40.3, A40.8, A40.9, A41.01, A41.02, A41.1, A41.2, A41.3, A41.4, A41.50, A41.51, A41.52, A41.53, A41.59, A41.81, A41.89, A41.9, A42.7, A54.86, B00.7, B37.7 N/A 
International Classification of Diseases, 10th Revision severe sepsis, septic shock R65.20, R65.21 N/A 

BIPAP, bilevel positive airway pressure; CPAP, continuous positive airway pressure; N/A, not applicable.

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