TABLE 1

Frequency of “Yes” Answers to MMAT Questions in Observational and Experimental Studies

n (%)a
Participants Are Representative of Target PopulationAppropriate MeasurementComplete Outcome DataConfounding Accounted forIntervention Administered as Intended
Observational (n = 225)b 136 (48) 224 (79) 252 (89) 260 (92) 277 (98) 
Experimental (n = 58) 6 (2) 258 (91) 195 (69) 93 (33) 249 (88) 
n (%)a
Participants Are Representative of Target PopulationAppropriate MeasurementComplete Outcome DataConfounding Accounted forIntervention Administered as Intended
Observational (n = 225)b 136 (48) 224 (79) 252 (89) 260 (92) 277 (98) 
Experimental (n = 58) 6 (2) 258 (91) 195 (69) 93 (33) 249 (88) 

Experimental studies include any experiment that was not randomized (natural experiment, quasi-experimental, etc).

a

“Yes” answers determined on the basis of consensus from a minimum of 2 coauthors; MMAT questions differed between RCTs and other study designs, see Methods for specific question language and scoring criteria.

b

For observational studies, “intervention administered as intended” indicates that the exposure of interest occurred as intended or expected. See Supplemental Table 6 for additional details.

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