Clinical Scenarios Involving >1 Organ System Dysfunction
| Description . | Defining Features . | Examples . |
|---|---|---|
| MODS | More than 1 concurrent organ system dysfunction arising from a common systemic pathobiological mechanism (or mechanisms) | Sepsis-induced cardiovascular, respiratory, and kidney dysfunction from systemic inflammation and mitochondrial energy failure |
| Trauma-induced cardiovascular, neurologic, and hepatic dysfunction from hemorrhage-induced global hypoperfusion | ||
| Hypertensive emergency leading to cardiac dysfunction and neurologic dysfunction | ||
| Sequential organ dysfunction | A primary organ dysfunction induces a secondary organ system dysfunction, but the underlying mechanisms are different | Primary cardiac dysfunction from an arrhythmia leading to secondary respiratory dysfunction from cardiogenic pulmonary edema |
| Primary liver failure from primary biliary cirrhosis leading to secondary neurologic dysfunction from hyperammonemia and cerebral edema | ||
| Primary kidney dysfunction from glomerulonephritis leading to secondary cardiac dysfunction from hypertension | ||
| Unrelated organ dysfunction | More than 1 concurrent organ system dysfunction, with each organ system dysfunction caused by a different mechanism | Respiratory dysfunction from pneumonia and kidney dysfunction from aminoglycoside-induced acute tubular necrosis |
| Cardiovascular dysfunction from sepsis and hematologic dysfunction from chemotherapy-induced bone marrow suppression |
| Description . | Defining Features . | Examples . |
|---|---|---|
| MODS | More than 1 concurrent organ system dysfunction arising from a common systemic pathobiological mechanism (or mechanisms) | Sepsis-induced cardiovascular, respiratory, and kidney dysfunction from systemic inflammation and mitochondrial energy failure |
| Trauma-induced cardiovascular, neurologic, and hepatic dysfunction from hemorrhage-induced global hypoperfusion | ||
| Hypertensive emergency leading to cardiac dysfunction and neurologic dysfunction | ||
| Sequential organ dysfunction | A primary organ dysfunction induces a secondary organ system dysfunction, but the underlying mechanisms are different | Primary cardiac dysfunction from an arrhythmia leading to secondary respiratory dysfunction from cardiogenic pulmonary edema |
| Primary liver failure from primary biliary cirrhosis leading to secondary neurologic dysfunction from hyperammonemia and cerebral edema | ||
| Primary kidney dysfunction from glomerulonephritis leading to secondary cardiac dysfunction from hypertension | ||
| Unrelated organ dysfunction | More than 1 concurrent organ system dysfunction, with each organ system dysfunction caused by a different mechanism | Respiratory dysfunction from pneumonia and kidney dysfunction from aminoglycoside-induced acute tubular necrosis |
| Cardiovascular dysfunction from sepsis and hematologic dysfunction from chemotherapy-induced bone marrow suppression |
Note that each scenario is not mutually exclusive.