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TABLE 2

Summary of Demographic Characteristics, Clinical Outcomes, and Scores of the Amendment and Validation Cohorts

CharacteristicsAmendment CohortValidation Cohort
No. patients 1121 12 241 
Age in y, median (IQR) 2.3 (4.7) 2.5 (3.8) 
Male sex, n (%) 621 (55.4) 6527 (53.3) 
Admitted to ward, n (%) 817 (72.9) 1481 (12.1) 
CC admission within 48 h, n (%) 47 (4.2) 135 (1.1) 
Hospital LOS, d, median (IQR) 3 (3) 1.04 (2.73) 
CC LOS, d, median (IQR) 2 (5) 2.23 (4.33) 
In-hospital mortality, n (%) 1 (0.09) 10 (0.08) 
Sepsis-related mortality, n (%) 1 (0.09) 5 (0.04) 
LqSOFA ≥2, n (%) 79 (7.0) 155 (1.3) 
LqSOFA ≥1, n (%) 369 (32.9) 1919 (15.7) 
qSOFA ≥2, n (%) 31 (2.8) 149 (1.2) 
qSOFA ≥1, n (%) 1027 (91.6) 11 579 (94.6) 
PEWS ≥3, n (%) — 1465 (12.0) 
PEWS ≥2, n (%) — 5211 (42.6) 
NICE high-risk criteria ≥2, n (%) 199 (17.8) 1357 (11.1) 
NICE high-risk criteria ≥1, n (%) 737 (65.7) 6787 (55.4) 
CharacteristicsAmendment CohortValidation Cohort
No. patients 1121 12 241 
Age in y, median (IQR) 2.3 (4.7) 2.5 (3.8) 
Male sex, n (%) 621 (55.4) 6527 (53.3) 
Admitted to ward, n (%) 817 (72.9) 1481 (12.1) 
CC admission within 48 h, n (%) 47 (4.2) 135 (1.1) 
Hospital LOS, d, median (IQR) 3 (3) 1.04 (2.73) 
CC LOS, d, median (IQR) 2 (5) 2.23 (4.33) 
In-hospital mortality, n (%) 1 (0.09) 10 (0.08) 
Sepsis-related mortality, n (%) 1 (0.09) 5 (0.04) 
LqSOFA ≥2, n (%) 79 (7.0) 155 (1.3) 
LqSOFA ≥1, n (%) 369 (32.9) 1919 (15.7) 
qSOFA ≥2, n (%) 31 (2.8) 149 (1.2) 
qSOFA ≥1, n (%) 1027 (91.6) 11 579 (94.6) 
PEWS ≥3, n (%) — 1465 (12.0) 
PEWS ≥2, n (%) — 5211 (42.6) 
NICE high-risk criteria ≥2, n (%) 199 (17.8) 1357 (11.1) 
NICE high-risk criteria ≥1, n (%) 737 (65.7) 6787 (55.4) 

PEWS not in use at the hospital when amendment cohort data were collected. IQR, interquartile range; LOS, length of stay; —, not applicable.

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