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TABLE 3

AUCs for Primary and Secondary Outcomes for LqSOFA, qSOFA, PEWS, NICE High-Risk Criteria, Lactate, and CRP in the Validation Cohort

Predictor and DefinitionPrimary Outcome: CC Admission Within 48 hSecondary Outcome: Sepsis-Related Mortality
AUC (95% CI)AUC (95% CI)
LqSOFA   
 LqSOFA score 0.81 (0.76 to 0.86) 0.87 (0.65 to 1) 
 LqSOFA ≥2 0.69 (0.64 to 0.75) 0.79 (0.53 to 1) 
 LqSOFA ≥1 0.78 (0.74 to 0.83) 0.82 (0.62 to 1) 
qSOFA   
 qSOFA score 0.66 (0.61 to 0.71) 0.81 (0.55 to 1) 
 qSOFA ≥2 0.64 (0.58 to 0.70) 0.79 (0.53 to 1) 
 qSOFA ≥1 0.53 (0.48 to 0.57) 0.53 (0.29 to 0.77) 
PEWS   
 PEWS 0.93 (0.90 to 0.95) 0.96 (0.92 to 1) 
 PEWS ≥3 0.88 (0.84 to 0.91) 0.94 (0.91 to 0.97) 
 PEWS ≥2 0.75 (0.72 to 0.78) 0.79 (0.68 to 0.90) 
NICE high-risk criteria   
 NICE high-risk criteria 0.81 (0.78 to 0.85) 0.72 (0.58 to 0.86) 
 NICE high-risk criteria ≥2 0.75 (0.70 to 0.80) 0.55 (0.28 to 0.81) 
 NICE high-risk criteria ≥1 0.70 (0.66 to 0.73) 0.72 (0.58 to 0.86) 
Lactate   
 Lactate 0.63 (0.56 to 0.69) 0.89 (0.71 to 1) 
 Lactate ≥4 mmol/L 0.58 (0.51 to 0.65) 0.85 (0.59 to 1) 
 Lactate ≥2 mmol/L 0.61 (0.55 to 0.68) 0.66 (0.41 to 0.92) 
CRP 0.55 (0.49 to 0.61) 0.83 (0.68 to 0.98) 
Predictor and DefinitionPrimary Outcome: CC Admission Within 48 hSecondary Outcome: Sepsis-Related Mortality
AUC (95% CI)AUC (95% CI)
LqSOFA   
 LqSOFA score 0.81 (0.76 to 0.86) 0.87 (0.65 to 1) 
 LqSOFA ≥2 0.69 (0.64 to 0.75) 0.79 (0.53 to 1) 
 LqSOFA ≥1 0.78 (0.74 to 0.83) 0.82 (0.62 to 1) 
qSOFA   
 qSOFA score 0.66 (0.61 to 0.71) 0.81 (0.55 to 1) 
 qSOFA ≥2 0.64 (0.58 to 0.70) 0.79 (0.53 to 1) 
 qSOFA ≥1 0.53 (0.48 to 0.57) 0.53 (0.29 to 0.77) 
PEWS   
 PEWS 0.93 (0.90 to 0.95) 0.96 (0.92 to 1) 
 PEWS ≥3 0.88 (0.84 to 0.91) 0.94 (0.91 to 0.97) 
 PEWS ≥2 0.75 (0.72 to 0.78) 0.79 (0.68 to 0.90) 
NICE high-risk criteria   
 NICE high-risk criteria 0.81 (0.78 to 0.85) 0.72 (0.58 to 0.86) 
 NICE high-risk criteria ≥2 0.75 (0.70 to 0.80) 0.55 (0.28 to 0.81) 
 NICE high-risk criteria ≥1 0.70 (0.66 to 0.73) 0.72 (0.58 to 0.86) 
Lactate   
 Lactate 0.63 (0.56 to 0.69) 0.89 (0.71 to 1) 
 Lactate ≥4 mmol/L 0.58 (0.51 to 0.65) 0.85 (0.59 to 1) 
 Lactate ≥2 mmol/L 0.61 (0.55 to 0.68) 0.66 (0.41 to 0.92) 
CRP 0.55 (0.49 to 0.61) 0.83 (0.68 to 0.98) 
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