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TABLE 3

Predictors of Moderate–Severe Illness Among Patients With Acute COVID-19, July 2020 to December 2021

PredictorUnadjusted n (%)aOR [95% CI]
Month of illness   
 July 2020–February 2021 1672 (4.9) Referent 
 March 2021 193 (6.3) 1.3 [1.1–1.6] 
 April 2021 269 (6.4) 1.3 [1.2–1.6] 
 May 2021 203 (9.8) 2.1 [1.8–2.5] 
 June 2021 101 (13.5) 2.8 [2.2–3.6] 
 July 2021 160 (9.4) 2.0 [1.7–2.4] 
 August 2021 423 (6.5) 1.5 [1.3–1.7] 
 September 2021 557 (7.2) 1.7 [1.5–1.9] 
 October 2021 377 (8) 1.8 [1.6–2.1] 
 November 2021 371 (7.2) 1.7 [1.5–1.9] 
 December 2021 855 (8.1) 1.7 [1.6–1.9] 
Age categories, y, n (%)   
 <1 1039 (13.1) 4.5 [4.1–4.9] 
 1–4 1415 (7.7) 2.1 [1.9–2.3] 
 5–11 1179 (4.1) Referent 
 12–17 1548 (6.2) 1.6 [1.4–1.7] 
Gender, n (%)   
 Male 2847 (6.8) 1.0 [1.0–1.2] 
 Female 2334 (6.0) Referent 
Race or ethnicity   
 Hispanic 1282 (9.1) 1.5 [1.4–1.6] 
 Non-Hispanic Black/African-American 1099 (6.9) 1.0 [0.9–1.06] 
 Asian American/Pacific Islander 130 (5.6) 0.9 [0.8–1.1] 
 Non-Hispanic White 2159 (5.8) Referent 
 Other/missing 511 (4.7) 0.8 [0.7–0.9] 
Health conditions   
 Asthma, no previous hospitalization 252 (3.9) 0.7 [0.6–0.8] 
 Asthma, previous hospitalization 529 (22.9) 2.9 [2.6–3.3] 
 Cancer, not actively treated 91 (25.1) 2.0 [1.4–2.8] 
 Cancer, actively treated 171 (65.0) 11.8 [8.3–16.8] 
 Cardiac disorder 789 (25.0) 2.7 [2.4–3.0] 
 Diabetes 156 (33.5) 6.3 [5.0–8.1] 
 Immunologic disorder 333 (35.4) 2.6 [2.2–3.2] 
 Mental health disorder 819 (10.0) 1.4 [1.2–1.5] 
 Obesity 1608 (9.5) 1.6 [1.4–1.7] 
 Prematurity 258 (15.4) 1.3 [1.1–1.5] 
 Renal disorder 347 (25.4) 1.8 [1.5–2.2] 
 Sickle cell disease 44 (26.7) 2.9 [1.9–4.5] 
 Trisomy 21 2 (10.0) 0.2 [<0.1–1.1] 
PredictorUnadjusted n (%)aOR [95% CI]
Month of illness   
 July 2020–February 2021 1672 (4.9) Referent 
 March 2021 193 (6.3) 1.3 [1.1–1.6] 
 April 2021 269 (6.4) 1.3 [1.2–1.6] 
 May 2021 203 (9.8) 2.1 [1.8–2.5] 
 June 2021 101 (13.5) 2.8 [2.2–3.6] 
 July 2021 160 (9.4) 2.0 [1.7–2.4] 
 August 2021 423 (6.5) 1.5 [1.3–1.7] 
 September 2021 557 (7.2) 1.7 [1.5–1.9] 
 October 2021 377 (8) 1.8 [1.6–2.1] 
 November 2021 371 (7.2) 1.7 [1.5–1.9] 
 December 2021 855 (8.1) 1.7 [1.6–1.9] 
Age categories, y, n (%)   
 <1 1039 (13.1) 4.5 [4.1–4.9] 
 1–4 1415 (7.7) 2.1 [1.9–2.3] 
 5–11 1179 (4.1) Referent 
 12–17 1548 (6.2) 1.6 [1.4–1.7] 
Gender, n (%)   
 Male 2847 (6.8) 1.0 [1.0–1.2] 
 Female 2334 (6.0) Referent 
Race or ethnicity   
 Hispanic 1282 (9.1) 1.5 [1.4–1.6] 
 Non-Hispanic Black/African-American 1099 (6.9) 1.0 [0.9–1.06] 
 Asian American/Pacific Islander 130 (5.6) 0.9 [0.8–1.1] 
 Non-Hispanic White 2159 (5.8) Referent 
 Other/missing 511 (4.7) 0.8 [0.7–0.9] 
Health conditions   
 Asthma, no previous hospitalization 252 (3.9) 0.7 [0.6–0.8] 
 Asthma, previous hospitalization 529 (22.9) 2.9 [2.6–3.3] 
 Cancer, not actively treated 91 (25.1) 2.0 [1.4–2.8] 
 Cancer, actively treated 171 (65.0) 11.8 [8.3–16.8] 
 Cardiac disorder 789 (25.0) 2.7 [2.4–3.0] 
 Diabetes 156 (33.5) 6.3 [5.0–8.1] 
 Immunologic disorder 333 (35.4) 2.6 [2.2–3.2] 
 Mental health disorder 819 (10.0) 1.4 [1.2–1.5] 
 Obesity 1608 (9.5) 1.6 [1.4–1.7] 
 Prematurity 258 (15.4) 1.3 [1.1–1.5] 
 Renal disorder 347 (25.4) 1.8 [1.5–2.2] 
 Sickle cell disease 44 (26.7) 2.9 [1.9–4.5] 
 Trisomy 21 2 (10.0) 0.2 [<0.1–1.1] 

aOR, adjusted odds ratio; CI, confidence interval.

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